Cat's claw is a wood vine that grows wild in central and South America, particularly in the Amazon rainforest. Historically, cat's claw has been used to prevent and treat disease dating back to the Inca civilization. Its inner bark is used to make liquids, capsules, and teas, and preparations can be applied to the skin. Cat's claw may have some properties to boost the immune system and reduce inflammation. Cat's claw has been examined for its effects on sleep-wake disturbances, fatigue, anxiety, and depression in patients with cancer.