Corticosteroids are a class of steroid hormones produced in the adrenal cortex. They are involved in a wide range of physiologic systems such as the stress and immune responses, the regulation of inflammation, carbohydrate metabolism, and protein catabolism. Corticosteroids can be administered orally, intravenously, or topically and are used to treat a variety of conditions. Drugs in this class include dexamethasone, methylprednisone, prednisone, hydrocortisone, mometasone, betamethasone, and fludrocortisones. Topical use of specific corticosteroids has been examined for its efficacy in treating radiodermatitis, skin reactions, and mucositis, and in the prevention of bleeding.