Gabapentin, an anticonvulsant, treats seizures by decreasing excitement in the brain. The medication works by changing the way the body senses pain. Researchers have studied the effects of gabapentin in patients with cancer who have neuropathic pain or symptoms of peripheral neuropathy. Gabapentin is also used in combination with other medications, such as opioids and imipramine, for the treatment of neuropathic pain and other symptoms. Researchers have also studied the effects of gabapentin on anxiety and hot flashes.

The U.S. Food and Drug Administration (FDA) has issued a warning regarding the use of gabapentin or pregabalin and serious breathing difficulties in people with respiratory risk factors, including older adults, those having conditions that reduce lung function such as chronic obstructive pulmonary disease (COPD), and those using drugs that depress the central nervous system including opioids, anti-anxiety medication, antidepressants, and antihistamines.