Granulocyte macrophage–colony-stimulating factor (GM-CSF) is a substance that binds to hemopoetic stem cells, activating them to profliferate and differentiate into granulocytes and macrophages. Colony-stimulating factors also have local effects related to immune response and wound healing; local application has been evaluated in the treatment of mucositis.  In this particular intervention, gauze was impregnated with GM-CSF solution and studied for its effect on prevention of radiodermatitis.