Hypnosis is a state between wakefulness and sleep, a state of heightened focal concentration and receptivity, an altered state of consciousness of a state of focused attention that results in suspension of peripheral cues. The effect of a hypnotic state results in alteration in perception and attention. Hypnosis has been tested for effect in pain, anxiety, depression, chemotherapy-induced nausea and vomiting (CINV), hot flashes, and fatigue in patients with cancer. Hypnosis has been delivered in various formats, including individual inperson sessions and use of a CD program for induction and training in self-hypnosis. Hypnosis has differing effectiveness according to the synthesis of evidence for CINV when used for anticipatory CINV versus for treatment of actual CINV.