An article by Duffy, Fitzgerald, Boyle, and Rohatgi (2018) was published in the April issue of the Clinical Journal of Oncology Nursing. Based on review, the authors suggested some clinical recommendations to protect the kidneys against cisplatin-induced nephrotoxicity, including hydration or supplementation of magnesium or mannitol during cisplatin administration. In addition to clinical findings, the related basic sciences data may be helpful in formulating treatment guidelines in cisplatin therapy. This letter will present several suggestions for future clinical studies based on laboratory findings.