The evolving field of radiation oncology has revolutionized treatment options for several malignancies. Advances in technology allow radiation oncologists to maximize the dose of radiation while minimizing damage to surrounding healthy tissue. Hypofractionated radiation, which reduces the frequency and number of treatments, is being studied in multiple tumor types. This modality often shortens a course of therapy by days or even weeks. Staying informed on emerging treatment modalities allows oncology nurses to educate patients on treatment plans and potential toxicities. This article explains the differences in radiation therapy modalities and focuses on hypofractionation and its benefits to patients.