Patients with cancer are at increased risk for readmission, which can be associated with increased healthcare costs and poor patient outcomes, because of the nature of the disease, treatment complexity, and symptom management. A melanoma medical oncology department at a National Cancer Institute–designated cancer center had a 22% 30-day readmission rate. Advanced practice RNs developed a structured program to improve patient teaching about postdischarge care and symptom management. No patients who received the structured discharge teaching program were readmitted within 30 days, compared to 11 out of 23 of patients admitted with immune-related toxicities preimplementation.