In response to the nursing shortage and the emergence of telehealth opportunities, the Oncology Nursing Society used an evidence-based approach to examine current literature and trends for the two-person independent double check of high-risk medications, such as chemotherapy, when one of those two individuals is working remotely. Analysis of available evidence suggests virtual technology for two-person independent double checks is feasible and may be equal to live two-person checks; however, lack of consistency and rigor in the interventions and outcome measures makes a determination on safety or efficacy challenging.