For the treatment of episodes of cancer-related breakthrough pain, the consensus of research supports administration of an opioid at a dose proportional to the total daily opioid intake. The proportional recommended dose is 10%–20% of the total daily basal dose. This recommendation does not apply to rapid-onset fentanyl.

National Comprehensive Cancer Network. (2011). NCCN Clinical Practice Guidelines in Oncology: Adult cancer pain [v. 2.2011.]. Retrieved from http://www.nccn.org/professionals/physician_gls/pdf/pain.pdf