Oxycodone is an opiate analgesic. Naloxone is a competitive opioid-receptor antagonist. At therapeutic oral doses, naloxone exerts a local inhibitory effect on opioid action in the gastrointestinal system. Researchers have studied oxydocone-naloxone, a combination medication, in regard to pain management and in regard to potential to reduce gastrointestinal side effects, such as constipation, in patients who require opioids for pain management.