Hyaluronic acid, also known as hyaluronate, is a carbohydrate substance that is present in connective, epithelial, and nerve tissues and is a major component of the intracellular matrix. Urea-containing lotion and creams are emollients for topical use and have keratolytic properties. Urea hydrates and breaks down the intercellular matrix, which results in mild debridement and proportion of normal healing of surface lesions. The topical combination of urea and hyaluronic acid was evaluated in patients with cancer for the management of radiodermatitis.