Multicomponent rehabilitative intervention may be understood as an interdisciplinary service aimed at ameliorating physical impairments, preventing the development of physical impairments and restrictions in activity and role performance that develop in association with cancer pathology (e.g., muscle weakness, self-care limitations, vocational limitations, disfigurement, speech and swallowing abnormalities, social integration), and preserving and restoring functional capability needed for purposeful activity. Multicomponent rehabilitative intervention encompasses an array of intervention approaches and may include intensive exercise, physical training, sports, psychoeducation, and physical modalities such as massage and manual lymph drainage. Multicomponent rehabilitative intervention has been evaluated in patients with cancer for management of anorexia, anxiety, cognitive impairment, depression, fatigue, lymphedema, pain, and sleep-wake disturbances.