MAS065D is a nonsteroidal water-in-oil cream that has barrier-forming, hydrating, and anti-inflammatory properties. It contains hyaluronic acid, shea butter (emollient), glycyrrhetinic acid (licorice extract with anti-inflammatory properties), Vitis vinifera (antioxidant activity), and telmesteine (anti-elastase and anticollagen activity in vitro). It is designed to reduce anti-inflammatory reactions and maintain a moist skin environment. Xclair has been used for radiodermatitis.