This article provides perspective from medical oncologists on the importance of this supplement from the Melanoma Nursing Initiative. The authors (a) delineate the challenges inherent in addressing adverse event (AE) management with newer melanoma therapies, particularly in the community setting; (b) illustrate how advanced practice providers with extensive clinical trial experience in melanoma are in a key position to set the agenda and educate colleagues on best practices in AE management; and (c) outline the rationale for the supplement and how it is uniquely tailored to enable community-based oncology nurses and allied health professionals caring for patients with melanoma to reduce the burden of AEs, support adherence, and improve patient outcomes.