Oncology Drug Reference Sheet: Pirobrutinib

In clinical trials, pirobrutinib (Jaypirca^™) was effective in restoring BTK inhibition in patients that experienced progression after previously receiving a covalent BTK inhibitor. Pirobrutinib became the first-available noncovalent (reversible) BTK inhibitor in January 2023 when the U.S. Food and Drug Administration granted it accelerated approval.