Treatment-Induced Ovarian Insufficiency and Early Menopause in Breast Cancer Survivors

Young women receiving systemic treatments for breast cancer are at risk for developing primary ovarian insufficiency and early menopause. Abrupt drops in estrogen levels often induce distressing vasomotor and vulvovaginal symptoms. Sustained estrogen deficiency related to treatment-induced early menopause can negatively affect long-term health outcomes. This article reviews the etiology of treatment-induced ovarian insufficiency and early menopause, discusses the effects of hypoestrogenism, and explores supportive care strategies to improve quality of life and long-term health for young breast cancer survivors.