5HT3 and Dexamethasone in Pediatric Patients
5-hydroxytryptamine (5-HT3) receptor antagonists (RAs) are a class of antiemetics used to relieve nausea and vomiting associated with chemotherapy. At this time, four 5-HT3 RAs are approved by the Food and Drug Administration (FDA) for use in the United States: ondansetron, granisetron, dolasetron, and palonosetron. Dexamethasone is a corticosteroid. These drugs have been evaluated for use in pediatric patients to treat acute emesis associated with highly or moderately emetogenic chemotherapy.
5HT3 and Anxiolytics in Pediatric Patients
Neurokinin 1 (NK1) receptor antagonists (RAs) are a class of drug used to treat nausea and vomiting in patients receiving chemotherapy. The class includes aprepitant, casopitant, and fosaprepitant. Anxiolytics are antianxiety agents used to treat the physical and psychological symptoms of anxiety. These drugs have been evaluated for use in pediatric patients to treat nausea and vomiting.