Zhao, Y., Tan, Y., Wu, G., Liu, L., Wang, Y., Luo, Y., . . . Huang, H. (2011). Berbamine overcomes imatinib-induced neutropenia and permits cytogenetic responses in Chinese patients with chronic-phase chronic myeloid leukemia. International Journal of Hematology, 94, 156–162.
The purpose of this study was to investigate whether berbamine has clinical benefit in reversing imatinib-related neutropenia. Berbamine is an alkaloid derived from the Berberis aristata plant that has been used in China for managing leukopenia associated with cancer and chemotherapy.
Patients self-selected, with consultation with their doctors, which treatment approach they wanted to have.
In patients who did not receive berbamine, the imatinib dose was adjusted according to guidelines so that those who developed an absolute neutrophil count (ANC) of less than 1.0 x 109/L had imatinib withheld until their ANC was 1.5 x 109/L or higher.
In the berbamine group, a daily dose of 336 mg orally was given to patients who developed grade 2 neutropenia (between the above 2 ANC levels) to prevent development of grade 3 or above. If grade 3 or above, the patients had imatinib withheld until they recovered to grade 1 or lower, and berbamine was continued until they had a stable count of an ANC of 2 x 109/L or greater for more than four weeks.
A single-site setting in China
Active antitumor treatment
Non-randomized two group comparison
Twenty patients chose to use berbamine and were treated preemptively. Incidence of grade 3 or higher neutropenia was 15% in the berbamine group and 38.5% in the comparison group—which was not a statistically significant difference.
Recovery time for patients treated with berbamine was a median of 42 days compared to 79 days in controls (p = 0.043). There was no difference between groups in disease response to treatment rates. The only adverse events with berbamine reported were symptoms of nausea in two patients.
Berbamine appears to be well tolerated by these patients overall. No firm conclusions can be drawn from this study.
Berbamine, a naturally occurring alkaloid compound from a Chinese traditional plant, may have some applicability and benefit for patients receiving imatinib for chronic myeloid leukemia. This particular study does not provide strong support for this use due to numerous study limitations. Further well-designed research with appropriate sample sizes in these types of patients, as well as other groups at risk for development of severe neutropenia, is warranted.
Zhao, Y.J., Khoo, A.L., Tan, G., Teng, M., Tee, C., Tan, B.H., . . . Chai, L.Y. (2016). Network meta-analysis and pharmacoeconomic evaluation of fluconazole, itraconazole, posaconazole, and voriconazole in invasive fungal infection prophylaxis. Antimicrobial Agents and Chemotherapy, 60, 376–386.
STUDY PURPOSE: To examine the efficacy and cost-effectiveness of various azoles for antifungal prophylaxis in patients with hematologic malignancies undergoing chemotherapy or cell transplantation
TYPE OF STUDY: Meta-analysis and systematic review
PHASE OF CARE: Active antitumor treatment
Overall, proven or probable fungal infection occurred in 5% of the study population—45% were Candida and 49% were Aspergillus. All triazoles were better than placebo, except for itraconazole. Various triazoles differed in terms of tolerability and specific treatment-related side effects. Comparative efficacy analysis was in favor of posaconazole based on numerous outcomes evaluated. Itraconazole was associated with more study withdrawals but was also the least costly. Incremental cost-effectiveness ratios (ICER) were calculated for each agent. This analysis showed that posaconazole had a higher ICER than comparators. All triazoles except for intraconazole capsules were found to be effective in reducing fungal infection.
The findings suggest that posaconazole may more cost-effective for antifungal prophylaxis than the other triazoles examined. Itraconazole capsules were not shown to be effective.
The findings showed that all azoles other than itraconzole capsules were effective for antifungal prophylaxis, and that posaconazole may be the most cost-effective agent.
Zhao, I., & Yates, P. (2008). Non-pharmacological interventions for breathlessness management in patients with lung cancer: A systematic review. Palliative Medicine, 22(6), 693-701.
The objective of the article was to review studies that evaluated nonpharmacologic interventions for breathlessness management in patients with lung cancer.
Databases searched were Cochrane Library, EMBASE, PubMed, Ovid, EBSCO Host as a search engine for CINAHL, Pre-CINAHL (2007), Health Source: Nursing/Academic Edition, and MEDLINE (all searched 1990-July 2007).
Search keywords were breathlessness, dyspnea, management, interventions, treatment, non-pharmacological, and lung cancer.
Nonpharmacologic interventions for breathlessness in patients with lung cancer were included.
Pharmacologic interventions for breathlessness, studies that did not include patients with lung cancer, descriptive studies, and studies not published in English literature were excluded.
One hundred sixty-nine abstracts were retrieved, 15 articles were reviewed, and five studies ultimately were included. Studies were eliminated based on selection criteria. Standardized abstraction procedures were used to evaluate included studies.
A total of 370 patients were in the five studies included [Corner (20), Bredin (103), Connors (14) , Hately (30), Moore (203)].
All studies included behavioral, psychological, and educational interventions, although the method of delivery varied between studies.
Evidence is moderately strong to suggest benefit of a counseling and supportive educational intervention to alleviate breathlessness in patients with lung cancer. While all studies showed benefit with a multicomponent nonpharmacologic intervention approach, whether all components are warranted or whether one component is more/less effective than another is inconclusive.
Studies were limited by small sample size or high attrition rates.
Nurses should consider providing support and counseling for breathing techniques, relaxation, and breathing retraining in patients with breathlessness and lung cancer.
Zhao, W.T., Hu, F.L., Li, Y.Y., Li, H.J., Luo, W.M., & Sun, F. (2013). Use of a transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer. World Journal of Surgery, 37, 227–232.
To determine if postoperative use of a transanal drainage tube after anterior resection surgery for rectal cancer would prevent anastomotic leakage and bleeding
In this study, patients were divided into either a transanal drainage tube (TDT) or the non-transanal drainage tube (NTDT) group. A 26 Fr tube was placed during surgery proximal to the anastomosis site. Then, an air leakage test and anastomotic bleeding test were performed. If either test were positive, then corrective surgical measures were employed prior to completion of the surgery. The tube was secured to the patient with a skin suture and connected to draining. The tube was removed approximately five to six days postoperatively. The study accepted patients from January 2007 through May 2011.
The study design was a nonrandomized, prospective trial.
A functional definition of anastomotic leakage and anastomotic bleeding were used. The anastomotic leakage definition addressed the drainage of stool, exudate, and gas from the abdominal and rectal drains or a rectovaginal fistula. Leakage was also considered present if peritonitis was present. Leaks were confirmed by CT scan, sigmoidoscopy, rectal examination, or laparotomy. Anastomotic bleeding was defined as continuous rectal bleeding from the rectal drain with a hemoglobin drop that no other cause could explain. Bleeding was confirmed by sigmoidoscopy, rectal examination, or laparotomy.
The use of a transanal tube to reduce bleeding in patients undergoing an anterior resection was not clinically significant. The study findings did not reach statistical significance, possibly due to the small population. However, the TDT group had 0% bleeding occur while the NTDT group experienced a 2.6% bleeding rate (p = 0.236). Of note, when anastomotic leakage was also considered, the TDT complication rate was 2.5% and the NTDT rate was 11.7%, which was clinically significant (p = 0.029).
Anastomotic bleeding is considered a complication of anterior resections. Physiological changes that occur postoperatively include a tight contraction of the anal sphincter, inflammation, pain, and trauma from the surgery. Placement of a transanal tube may be considered a mechanism for addressing some of these changes occurring postoperatively, therefore reducing bleeding.
Educational opportunities exist for nurses to instruct patients preoperatively regarding the possible placement of a transanal tube postoperatively, with the rationale for its use to ease the postoperative recovery. Standardization of instruction for nursing staff regarding \"normal\" versus abnormal amounts and types of bleeding/drainage from tubes is necessary.
Zhang, R.X., Wu, X.J., Lu, S.X., Pan, Z.Z., Wan, D.S., & Chen, G. (2011). The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: A phase II randomized prospective study. Journal of Cancer Research and Clinical Oncology, 137, 953–957.
Capecitabine is hypothesized to cause overexpression of COX-2 in tumor and healthy tissue, inducing hand-foot syndrome (HFS). This prospective clinical trial will address whether the addition of a COX-2 inhibitor plus capecitabine can decrease or ease HFS.
Patients were randomly assigned to adjuvant treatment with capecitabine plus oxaliplatin or capecitabine alone, with or without celecoxib. The COX-2 inhibitor dose was 200 mg/m2 BID in combination with capecitabine for 14 days. Adverse events were monitored continuously during treatment and for 30 days after the last dose of study drug. The intensity of adverse events was graded according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), version 4.0.
Patients were undergoing the active treatment phase of care.
This was a randomized, prospective phase 2 clinical trial.
HFS was evaluated according to the NCI CTCAE, version 4.0.
Celecoxib was safe and convenient for patients receiving chemotherapy and reduced the incidence of lower grade HFS.
In the correct population of patients, COX-2 inhibitors can be suggested. Additional research in this area is warranted.
Zhang, L., Fan, A., Yan, J., He, Y., Zhang, H., Zhang, H., . . . Xin, M. (2016). Combining manual lymph drainage with physical exercise after modified radical mastectomy effectively prevents upper limb lymphedema. Lymphatic Research and Biology, 14, 104–108.
To evaluate the efficacy of self-manual lymph drainage (MLD) added to physical exercise for the prevention of lymphedema and scar formation
Self MLD for a total 30 minutes, three sessions a day, after incision closure and suture removal was divided into three steps: Surgical incision scar (10 minutes a session), activate lymph nodes (10 minutes a session), ,stimulate lymph drainage (10 minutes a session). All patients were to continue active remedial exercises for six months following surgery. Women with breast cancer scheduled for surgery were randomly assigned to physical exercise (control) or self MLD plus exercise, with measurements for limb circumference and shoulder abduction recorded 24 hours before and after surgery at week 1, and at 1, 3, 6, and 12 months; evaluation of scar formation was conducted after suture removal at week 1, and at 1, 3, 6, and 12 months.
PHASE OF CARE: Multiple phases of care
Fewer patients in the MLD group had scar contracture (p < 0.05, MLD versus PE). Prevalence of upper limb lymphedema was lower in the MLD group at various time points (p < 0.05, MLD versus PE). Maximum shoulder abduction was better in the MLD group (p < 0.05, MLD versus PE).
The findings suggest that self-administered MLD with exercise was more effective in preventing lymphedema than exercise alone.
Patient education regarding the lymphatic system, self MLD, combined with physical exercise and adherence to the therapeutic routine may help in preventing scar formation, shoulder dysfunction, and upper extremity lymphedema.
Zhang, L., Huang, Z., Wu, H., Chen, W., & Huang, Z. (2014). Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. European Journal of Oncology Nursing, 18, 626–629.
To evaluate the effect of swallowing training on dysphagia and depression in postoperative patients with tongue cancer
The WST and SDS scores were significantly lower in the less than 50% tongue resection and rehabilitation group, and also in the early tumor stage group as opposed to the advanced stage group. There was no significant differences in WST and SDS based on age, flap defect rehabilitation, neck dissection, or range of mandibulectomy. WST levels and SDS scores before swallowing training were significantly greater than after training (WST: p = 0.027, SDS: p = 0.034). In all cases, lower WST scores were associated with lower SDS scores.
Improved swallowing may reduce severity of depression. Improving functional outcomes, such as eating, is a significant quality-of-life issue.
This is an important issue for nurses in developing and implementing interventions to improve quality of life and survivorship. Swallowing retraining can potentially be effective for both swallowing and depression associated with the disease process.
Zhang, R.X., Wu, X.J., Wan, D.S., Lu, Z.H., Kong, L.H., Pan, Z.Z., & Chen, G. (2012). Celecoxib can prevent capecitabine-related hand-foot syndrome in stage II and III colorectal cancer patients: Result of a single-center, prospective randomized phase III trial. Annals of Oncology, 23, 1348–1353.
To compare the incidence and severity of hand-foot syndrome (HFS) in patients who received capecitabine with and without celecoxib.
Patients were randomized to receive oral celecoxib 200 mg BID or no intervention. Sampling was stratified based on the specific chemotherapy regimen used. Patients were educated on how to prevent side effects of therapy and monitored weekly with telephone calls and monthly clinic visits.
Patients were undergoing the active antitumor treatment phase of care.
This was a randomized, prospective trial.
National Cancer Institute (NCI) common toxicity criteria (CTC), version 4
Celecoxib as used in this trial may delay the onset and severity of HFS in patients receiving capecitabine-based chemotherapy. In addition, celecoxib was not associated with adverse events.
Use of anti-inflammatory medications such as celecoxib may help delay the onset and severity of HFS in patients receiving capecitabine-based chemotherapy. In addition, no adverse events were reported with use as long as six months.
Zhang, Y., Zhang, S., & Shao, X. (2013). Topical agent therapy for prevention and treatment of radiodermatitis: A meta-analysis. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 21(4), 1025–1031.
To review the evidence regarding efficacy of topical treatments to prevent and manage radiodermatitis through meta-analysis and systematic review
Databases searched were Cochrane, MEDLINE, PubMed, and Web of Science. Keywords used were radiodermatitis, skin reaction, prevention, treatment, erythema, and desquamation, among others. Studies were included in the review if they
Seventy-three references were retrieved. Study quality was rated using the Jadad Scale.
Effect of topical agents for prevention showed no significant differences across all trials between intervention and control groups (relative risk [RR] = 0.90) There was no significant difference across control and intervention groups for topical agent use in wound healing (RR = 1.01). There was high heterogeneity in both analyses. All topical agents were considered together, with no analysis of different types of agents.
Findings suggest that overall, the use of topical agents is not effective for either prevention or treatment of radiodermatitis. The findings are similar to those of other systematic reviews in the topic that have shown there is insufficient evidence in this area to recommend any particular topical agent.
There is a continued need for well-designed research in the area of prevention and management of radiodermatitis.
Zhang, L.L., Wang, S.Z., Chen, H.L., & Yuan, A.Z. (2016). Tai chi exercise for cancer-related fatigue in patients with lung cancer undergoing chemotherapy: A randomized controlled trial. Journal of Pain and Symptom Management, 51, 504–511.
To assess the effectiveness of Tai Chi in managing cancer-related fatigue
Patients were randomized to the Tai Chi or low-impact exercise groups. Tai Chi was taught by instructors in the community and via DVD. Patients were enrolled during hospitalization for chemotherapy. Sessions were conducted for 12 days during each course of chemotherapy every other day across four courses of treatment. Study assessments were conducted prior to the first and third courses of chemotherapy and at the end of the fourth course.
Fatigue scores increased in all patients. At six weeks, general and physical fatigue subscale scores were lower in the Tai Chi group (p < 0.05). Vigor scale scores were higher in the Tai Chi group (p < 0.05). These scores were also better in the Tai Chi group at 12 weeks (p < 0.05). No other differences existed between groups.
Tai Chi was beneficial for patients with lung cancer to reduce treatment-related fatigue while undergoing chemotherapy.
The findings suggest that Tai Chi can be an effective intervention to combat fatigue during cancer treatment with chemotherapy. Exercise has been shown to be an effective intervention, and patients who did Tai Chi experienced less fatigue than those doing low-impact exercise. This study had multiple limitations, so the strength of this finding is limited. Additional research is warranted to provide strong support for this intervention.