Van de Wetering, M.D., Van Woensel, J., & Lawrie, T.A. (2013). Prophylactic antibiotics for preventing gram positive infections associated with long-term central venous catheters in oncology patients. Cochrane Database of Systematic Reviews, 11, CD003295.
STUDY PURPOSE: To determine the effectiveness of administering antibiotics prior to long-term central venous catheter (CVC) insertion, or flushing to prevent catheter-related infections
TYPE OF STUDY: Meta-analysis and systematic review
PHASE OF CARE: Not specified or not applicable
APPLICATIONS: Pediatrics
Five studies evaluated prophylactic antibiotic administration prior to CVC insertion, and six studies evaluated flush or catheter lock solutions. Pooled analysis of evidence comparing antibiotic and heparin solution to heparin only solution showed that the combination of antibiotic was associated with less catheter-related sepsis than the heparin only solution (468 participants, relative risk [RR] = 0.47, 95% confidence interval [CI] [0.28, 0.8], p = 0.0051). The majority of these instances were in children, and low heterogeneity existed among these studies. Five of the six studies used vancomycin in the flush mixture. No difference existed in the risk of catheter-related infections between those who did and did not receive prophylactic antibiotics prior to CVC insertion.
This review did not demonstrate a beneficial effect of prophylactic antibiotics prior to long-term CVCD insertion. The findings suggest that the use of antimicrobial catheter flush or lock solutions may be helpful for infection reduction from gram-positive organisms; however, the majority of studies used vancomycin, which has been not recommended for standard use.
The use of catheter flush and lock solutions that contain a combination of antibiotics and heparin may help prevent or reduce catheter-related infection in patients with long-term tunneled central venous catheters.
van der Spoel, J.I., Oudemans-van Straaten, H.M., Kuiper, M.A., van Roon, E.N., Zandstra, D.F., & van der Voort, P.H. (2007). Laxation of critically ill patients with lactulose or polyethylene glycol: A two-center randomized, double-blind, placebo-controlled trial. Critical Care Medicine, 35, 2726–2731.
To determine whether lactulose or polyethylene glycol (PEG) effectively promotes bowel function in critically ill patients, and to identify whether one is superior to the other.
On day 3 in critical care, consenting patients who had no bowel movements were randomized to one of three arms: lactulose, PEG 3350, or placebo. The lactulose solution was 13 gm of lactulose in 100 ml of sterile water. The PEG 3350 solution was 13.125 gm of PEG 3350 in 100 ml of sterile water. Finally, the placebo was 100 ml of sterile water. Each patient was medicated with the study liquid every eight hours via a nasogastric tube and was to receive 11 doses of treatment medication.
Two ICUs in the Netherlands
This was a double-blind, placebo-controlled, randomized trial.
Both lactulose and PEG promoted bowel movements equally. In patients receiving morphine, PEG had a more significant effect.
The study lacked a lead-in period or data on patients’ prior bowel function and history of constipation.
Bowel function is promoted with the use of either lactulose or PEG. Lactulose may reduce LOS, and PEG may be better for patients who also are receiving morphine, but additional study is needed.
van der Peet, E.H., van den Beuken-van Everdingen, M.H., Patijn, J., Schouten, H.C., van Kleef, M., & Courtens, A.M. (2009). Randomized clinical trial of an intensive nursing-based pain education program for cancer outpatients suffering from pain. Supportive Care in Cancer, 17, 1089–1099.
To investigate the effect of intensive home-based nurse-provided education on pain levels, pain knowledge, quality of life, anxiety, and depression in patients with cancer
Patients with cancer were randomized to receive either a pain education intervention or usual care. Pain, knowledge, quality of life, anxiety, and depression were measured at baseline and after four and eight weeks. In the intervention group, effects on symptom levels were communicated to the treating physician. The program included a brochure about pain management, instructions about how to record pain intensity in a diary, and simulation of help-seeking behavior. In the intervention group, palliative care nurses made three home visits. After these visits, nurses communicated with the physician, by means of a written report of pain control and recommendations regarding dose or medication changes. Home visits were at weeks 1, 3, and 6. Follow-up telephone calls to members of the intervention group occurred at weeks 4 and 8.
Randomized controlled trial
At four weeks, the level of pain had decreased in the intervention group (p = 0.02) but not at eight weeks. Significant decreases in pain only persisted in those patients with a high pain score (7–10) at baseline (p = 0.00). Knowledge of pain was significantly increased in the intervention group at week 8 (p < 0.00). Authors found no correlation between increased pain knowledge and decreased pain levels. In 60% of cases, recommendations in nurses' reports were ignored.
In the short term, the nurse-administered pain-related education program lowered pain intensity in patients with cancer and increased patients' knowledge about pain.
In regard to pain and pain management, additional attention must be paid to patient education and to communication between patients and healthcare professionals. The following components should be characteristic of patient education programs: involvement of the patient and family or caregivers, communication with the patient to reinforce information and monitor the plan, integration of medical care into the nursing education program, clear instructions regarding provider notification, and use of a pain diary. The components have the potential to reduce pain. Study findings showed that communications to physicians, written by palliative care nurses, were ignored 60% of the time, suggesting that this form of communication is ineffective. Educating the patient and helping patients to self-advocate in interactions with physicians are important goals.
van der Meulen, I.C., May, A.M., de Leeuw, J.R., Koole, R., Oosterom, M., Hordijk, G.J., & Ros, W.J. (2014). Long-term effect of a nurse-led psychosocial intervention on health-related quality of life in patients with head and neck cancer: A randomised controlled trial. British Journal of Cancer, 110, 593–601.
To report on health-related quality of life (HRQOL) and depressive outcomes from an earlier trial using nurse counseling after intervention (NUCAI)
Nurses delivered as many as six 45–60 minutes sessions every two months. The sessions consisted of six components: completing a Hospital Anxiety and Depression Scale before each session to lead a discussion of current mental state, having a discussion of current physical problems, having a discussion of life functioning, providing the AFTER (Adjustment to Fear, Threat, or Expectation of Recurrence) intervention, providing general medical assistance, and referring patients to psychological care. The AFTER intervention had four components: expressing fear of recurrence, identifying beliefs about recurrence, evaluating self-examinations, reducing excessive checking behavior, and relaxation. Usual care was provided twice monthly in sessions about complications and monitoring for recurrence. Patients were referred for psychological aftercare if psychosocial problems were assessed.
Single, blinded, randomized, controlled trial
50% of patients were lost to follow-up, the majority of which were because of death or terminal disease. At 12 months, statistically significant differences in physical functioning, emotional functioning, pain, swallowing, social contact, opening the mouth, coughing, and depressive symptoms were present. At 18 months, statistically significant differences in global quality of life, role functioning, emotional functioning, pain, swallowing, opening mouth, and depressive symptoms were present. At 24 months, statistically significant differences in emotional functioning and fatigue were present. Appointments were difficult to complete at times because of the clinic environment.
The NUCAI showed significant improvements for patients with head and neck cancer 24 months after completing treatment.
As a nurse-led intervention, this is a feasible option for patients with head and neck cancer desiring a problem-focused intervention for symptoms.
van der Meulen, I.C., May, A.M., Ros, W.J., Oosterom, M., Hordijk, G.J., Koole, R., & de Leeuw, J.R. (2013). One-year effect of a nurse-led psychosocial intervention on depressive symptoms in patients with head and neck cancer: A randomized controlled trial. The Oncologist, 18, 336–344.
To investigate the effects of a psychosocial nurse counseling and after intervention (NUCAI) versus usual care on symptoms of depression and physical symptoms related to the head or neck cancer (HNC) of patients one year after the diagnosis of HNC.
The NUCAI consisted of six bimonthly 45-minute counseling sessions. NUCAI is a problem-focused method aimed at helping patients to manage the physical, psychological, and social consequences of HNC and its treatment. The intervention consisted of these components: evaluating current mental status, discussing current problems, systematically asking about physical problems and functioning, and providing the adjustment to the fear, threat or expectation of recurrence (AFTER) intervention. AFTER was nurse led. During one year, six sessions were provided with usual and regular medical follow-up visits. Usual care involved 10-minute appointments every two months, for examination and review. Patients were randomly assigned to the intervention or control group. Data were collected every three months for one year.
Transition phase after active treatment
Randomized controlled trial
Study findings showed significant reduction in depression; therefore, this intervention can be used in clinical settings to improve patient outcomes (e.g., reduction of depression and improvement of physical symptoms).
This study utilized a nurse-led intervention for reduction of symptoms of depression in HNC patients. With proper training nurses can be equipped with the skill of providing psychological counseling to patients. Investigators noted that, compared to the cost of counseling offered by a clinical psychologist or psychiatrist, the nurse-led intervention seems a cost-effective method.
van der Lee, M. L., & Garssen, B. (2012). Mindfulness-based cognitive therapy reduces chronic cancer-related fatigue: a treatment study. Psycho-Oncology, 21, 264–272.
To evaluate the efficacy of group mindfulness-based cognitive therapy (MBCT) in reducing fatigue in cancer survivors with mixed diagnoses.
Randomization and assignment to either the intervention condition or the wait-list condition was performed one week prior to the start of each group. Fatigue severity (Checklist Individual Strength [CIS]), functional impairment (Sickness Impact Profile [SIP]), and well-being (Health and Disease Inventory) were assessed before and after the nine-week intervention. The intervention group had a follow-up six months after the intervention.
Eighty-three patients (32% male, 68% female) were included. All cancer types were included; more than half of the patients had breast cancer. Three patients had a history of two types of cancer.
Patients were included if
Patients were excluded if they were seen on intake by one of two therapists for assessment of psychiatric morbidity or if they were identified to be at risk for psychosis or severe depression.
The study used a pre- and postrandomized, controlled trial design.
Ninety-one percent of all participants attended at least seven sessions; the mean number of sessions attended was eight. One-third (30.6%) of all participants suffered from sleep disturbances at follow-up, and 39% in the intervention group showed clinically relevant improvement in fatigue severity. Fatigue severity postintervention was 35.7 in the intervention group compared to 43.4 in the control group (p = 0.00). The effect size for fatigue was 0.74 (d) (no confidence interval was provided for effect size). The mean well-being score at postmeasurement was significantly higher in the intervention group than in the wait-list group. Six months after the intervention, participants in both groups reported significantly less fatigue severity. There was no difference between groups in fatigue at six months.
MBCT was effective in the short term for chronic cancer-related fatigue (CCRF). Longer-term follow-up showed no differences with mindfulness-based stress reduction versus the controls.
MBCT is an acceptable and potentially effective treatment for CCRF. Additional better randomized, controlled trials of the intervention should be conducted prior to routinely referring to MBCT therapists.
van den Hurk, D.G., Schellekens, M.P., Molema, J., Speckens, A.E., & van der Drift, M.A. (2015). Mindfulness-based stress reduction for lung cancer patients and their partners: Results of a mixed methods pilot study. Palliative Medicine, 29, 652–660.
To assess the feasibility of a mindfulness-based stress reduction (MBSR) intervention for patients with lung cancer and their partners, and to determine whether MBSR decreases distress in the same population
Participants received eight weekly sessions (two and a half hours each) of an MBSR course with an additional psychoeducational component of coping with grief taught by health professionals and qualified mindfulness trainers. Assessments were made at baseline, postintervention, and three months later.
Pre- and post-test, single-arm feasibility study
An MBSR intervention for patients with lung cancer and their partners was feasible. No statistically significant change in anxiety and depression or mindfulness and worry were observed in patients or partners. Caregiver burden decreased after the MBSR training post-treatment (p < 0.05), and at the three month follow-up (p < 0.01). Six patients and five partners were able to report on facilitators (participating with partner and in group) and barriers (physical function) to participating as well as themes of process of change (standing still, being aware, insight, letting go, and changing behavior and acceptance).
MBSR is feasible for patients with lung cancer and their partners.
MBSR may be an effective intervention for decreasing caregiver burden in the lung cancer population. Additional research is needed in larger randomized, controlled trials.
van den Berg, M., Visser, A., Schoolmeesters, A., Edelman, P., & van den Borne, B. (2006). Evaluation of haptotherapy for patients with cancer treated with chemotherapy at a day clinic. Patient Education and Counseling, 60, 336–343.
Five haptotherapy intervention sessions were given during the period of chemotherapy, according to the wishes of the patient. Outcomes were quality of life (QOL), mood, meaning in life, general functioning, physical and psychological symptoms, sleep quality, and body awareness.
Patients were undergoing the active treatment phase of care.
This was a nonrandomized, exploratory study with a quasiexperimental design with an intervention and matched control group, which were both studied pre- and posttest.
Haptotherapy treatment improved the perceived general QOL and the perceived cognitive and social functioning of the patients. No improvement was found for mood, meaning in life, general functioning, physical symptoms, sleep quality, or body awareness.
van den Berg, M., Visser, A., Schoolmeesters, A., Edelman, P., & Borne, B. (2006). Evaluation of haptotherapy for patients with cancer treated with chemotherapy at a day clinic. Patient Education and Counseling, 60, 336–343.
The intervention consisted of five 45-minute haptotherapy sessions given during the period of chemotherapy as the patient desired. The mean time between the first and last session was 11.5 weeks (range 3–36). Sessions were performed by two haptotherapists on days when patients received chemotherapy. The first session included an introduction to haptotherapy and a preliminary interview reviewing patient goals for treatment. After establishing the needs of the patient, the therapist sought to bring the patient in contact with his/her body and feelings through the means of touch. Through contact, patients opened up emotionally and began to speak more freely about their feelings. Conversation and physical contact both are part of the treatment and cannot be viewed separately. The treatment often involved the back, legs, feet, belly, neck, and shoulders.
Patients in the intervention group were recruited from the day clinic of the Diakonessenhuis Zeist. Patients from the control group were from three other hospitals in the Utrecht region.
Patients were undergoing the active treatment phase of care.
The study used a nonrandomized, pre-/posttest semiexperimental design, with 31 patients in the haptotherapy group and 26 in the control group.
The intervention group experienced decreased fatigue from pretest to posttest according to EORTC evaluation. Conversely, the control group experienced increased fatigue from pretest to posttest assessment. The observed differences did not reach statistical significance.
van de Wetering, M.D., de Witte, M.A., Kremer, L.C., Offringa, M., Scholten, R.J., & Caron, H.N. (2005). Efficacy of oral prophylactic antibiotics in neutropenic afebrile oncology patients: A systematic review of randomized controlled trials. European Journal of Cancer, 41, 1372–1382.
To compare oral-based prophylactic antibiotics (quinolone-based prophylaxis or trimethoprim/sulfamethoxazole (TMP/SMZ)-based regimens) with placebo or no prophylaxis. Trials considering patients with cancer (both adults and children) undergoing chemotherapy in which oral prophylactic antibiotics were started before the expected onset of neutropenia were included.
DATABASES USED: MEDLINE from 1966–October 2002, EMBASE from 1988–October 2002, and the Cochrane Central Register of Controlled Trials, issue 2, 2002; the references were checked for additional articles. Authors of included papers were contacted.
Antibacterial prophylaxis (TMP/SMZ or quinolones) significantly reduced bacteremia by 57% and infection-related mortality. Quinolones significantly reduced the risk of gram-negative bacteremia, but TMP/SMZ did not. TMP/SMZ significantly reduced the risk of gram-positive bacteremia, but quinolones did not. No significant increase was reported in the risk of fungemia or fungal-related mortality with antibacterial prophylaxis. In subgroup analyses, a significant reduction was found in bacteremia in patients undergoing conventional chemotherapy and bone and marrow transplantation.