Saif, M.W., & Elfiky, A.A. (2007). Identifying and treating fluoropyrimidine-associated hand-and-foot syndrome in white and non-white patients. Journal of Supportive Oncology, 5, 337–343.
Multiple interventions can be implemented to prevent or minimize PPE, including teaching patients to avoid friction and exposing their skin to heat.
Sahler, O.J.Z., Hunter, B.C., & Liesveld, J.L. (2003). The effect of using music therapy with relaxation imagery in the management of patients undergoing bone marrow transplantation: A pilot feasibility study. Alternative Therapies, 9(6), 70–74.
A 45-minute music-assisted intervention with relaxation imagery sessions was provided twice a week by a trained therapist from the date of enrollment in the study to discharge.
The study was conducted at a university bone marrow transplant center.
Patients were undergoing the active treatment phase of care.
The study had a case-controlled, nonrandomized convenience sample design.
Patient self-reported pre- and postintervention nausea and pain on a 0–10 scale. Time to engraftment also was measured.
Nausea, pain, and time to engraftment decreased from pre- to postintervention.
The intervention was implemented successfully with a very ill population (i.e., transplant environment).
Sahin, Z.A., & Erguney, S. (2016). Effect on symptom management education receiving patients of chemotherapy. Journal of Cancer Education, 31, 101–107.
To examine the effect of a planned educational program on symptom control
Patients were randomly assigned to the education or waitlist control/usual care group. The educational intervention consisted of face-to-face educational sessions prior to each chemotherapy cycle provided to patients, caregivers, and family members. Symptom management education, support, and opportunity for discussion were provided.
PHASE OF CARE: Active antitumor treatment
Randomized, controlled trial
Not specified
The prevalence of chemotherapy-induced nausea and vomiting and difficulty sleeping were significantly lower after the intervention in the education group (p < 0.001), whereas the prevalence of these symptoms increased in the control group.
The findings suggest that an educational intervention can be beneficial in managing symptoms related to cancer treatment.
Patient education may be helpful in managing symptoms during cancer treatment. Education is necessary but may not be sufficient for symptom control.
Sahawneh, L.J.F. (2011). Effectiveness of therapeutic touch on pain management among patients with cancer -- literature review. Middle East Journal of Nursing, 5(4), 21–24.
To conduct a systematic review to evaluate the effectiveness of therapeutic touch (TT) as a complementary or alternative means of managing the pain of patients with cancer
TT is a therapy that may be useful in decreasing cancer-related pain and improve quality of life, but TT is often overlooked.
The systematic review was not thorough; reported findings were not comprehensive.
Sagiroglu, G., Meydan, B., Copuroglu, E., Baysal, A., Yoruk, Y., Altemur Karamustafaoglu, Y., & Huseyin, S. (2014). A comparison of thoracic or lumbar patient-controlled epidural analgesia methods after thoracic surgery. World Journal of Surgical Oncology, 12, 96-7819-12-96.
To compare the hemodynamic and analgesic effects of patient-controlled thoracic or lumbar epidural analgesia methods in a prospective, randomized study design after thoracotomy operations
One hundred and twenty patients were prospectively randomized to receive either thoracic epidural analgesia (TEA group) or lumbar epidural analgesia (LEA group) for a 24-hour postoperative period. Epidural catheters were administered in both groups. Hemodynamic measurements, Visual Analog Scale scores at rest (VAS-R) and after coughing (VAS-C), analgesic consumption, and side effects were compared at 0, 2, 4, 8, 16, and 24 hours postoperatively.
All measurements were compared at 0, 2, 4, 8, 16, and 24 hours postoperatively.
The VAS-R and VAS-C values were lower in the TEA group when compared to the LEA group at 2, 4, 8, and 16 hours after surgery. The total 24-hour consumption of analgesics was lower in the TEA group. The incidence of hypotension, bradycardia, atelectasis, and the need for intensive care unit treatment was lower in the TEA group. There was no difference in incidence of cardiac or pulmonary complications or the occurrence of epidural morphine-related side effects. Both techniques provided efficient analgesia.
TEA had beneficial hemostatic effects and satisfactory pain relief after thoracotomies in comparison to LEA.
Epidural analgesia is used after a thoracotomy to diminish the incidence of possible pulmonary and cardiac complications. TEA has beneficial hemodynamic effects in comparison to LEA after thoracotomies along with a more satisfactory pain relief profile during the 24-hour postoperative period.
Sagen, A., Karesen, R., & Risberg, M.A. (2009). Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randomized controlled trial with two years follow-up. Acta Oncologica (Stockholm, Sweden), 48(8), 1102–1110.
To study the development of arm lymphedema, pain, and sensation of heaviness in the affected limb after different postoperative rehab programs that involve different physical activity levels of the upper limbs
Women were randomized to one of two groups after surgery: no activity restriction (NAR) and activity restrictions (AR). Patients in the NAR group had a supervised physical therapy program in an outpatient clinic, emphasizing progressive resistance training two to three times per week. Patients in the NAR group were given standard detailed information on the unrestricted program. The AR group was told to restrict use of the affected limb for six months, including avoidance of aerobic or other types of exercise involving heavy upper-limb activity, and to avoid carrying or lifting anything more than 3 kg. Patients in the AR group also participated in the usual care physical therapy, which included six different passive techniques emphasizing flexibility and light massage. Usual care was provided for six months. Arm volumes were measured as three months, six months and two years.
The study took place at a mutlisite, outpatient setting in Norway.
The study used a randomized, single-blind, controlled trial design.
Mean duration of the rehabilitation programs was 21 weeks for the NAR group and 22 weeks for the AR group. Arm volumes at three months, six months and two years did not differ between study groups. In both groups arm edema increased significantly over time. VAS ratings for pain and heaviness for the affect limb were significantly higher in the NAR group at three months and six months (p < 0.05) but did not differ between groups at two years. Individuals with a body mass index greater than 25 kg/m2 had in increased risk of developing arm lymphedema (OR 3.42, p < 0.005) at two years. At three and six months, the amount of home physical activity reported by the NAR group was significantly higher (p = 0.001), but there were no differences in this finding between groups at two years. Approximately 13% of patients in each group had arm lymphedema at two years.
During activity participation in rehabilitation it appears that the use of progressive resistance activity and no activity restrictions were associated with more pain and sensation of heaviness with physical activity than usual care in the short term; however, there were no differences in longer-term development of lymphedema or associated symptoms. Findings suggest that activity restriction does not result in improved outcomes.
Findings suggest that doing progressive resistance exercise may help reduce lymphedema symptoms in the short term among women after breast cancer surgery because those who had restricted activity had no difference in symptoms in longer-term outcomes in the study. Given the relation between high body mass index and lymphedema development, it would be of interest to study whether weight control and weight loss after surgery would have any impact on lymphedema development.
Sagara, Y., Sato, K., Fukuma, E., Higaki, K., Mizutani, M., Osaki, A., . . . Saeki, T. (2013). The efficacy and safety of FSK0808, filgrastim biosimilar: A multicenter, non-randomized study in Japanese patients with breast cancer. Japanese Journal of Clinical Oncology, 43, 865–873.
To assess the efficacy and safety of daily FSK0808 injections to treat neutropenia in patients with breast cancer
Daily injections of FSK0808 were used to treat neutropenia experienced by patients in the course of chemotherapy treatment.
Efficacy was measured by drawing blood to calculate the patients’ absolute neutrophil count. Vital signs also were performed to assess patients for fever.
The study showed that FSK0808 reduced the recovery time from neutropenia caused by the treatment of breast cancer with FEC100. The average of 2.2 days of neutropenia was comparable to the 2.1 days reported in a comparative study that used filgrastim. Adverse drug reactions were similar to those experienced with filgrastim, and most events were mild.
FSK080 is safe and well tolerated in patients with breast cancer going through chemotherapy and successfully stimulated neutrophil recovery.
This study shows that FSK0808 is a safe and viable alternative to filgrastim, meaning that nurses will have to familiarize themselves with the use and side effects of this new medication.
Sadoon, M., & Al-Atiyyat, N. (2013). The efficacy of manual lymph drainage for breast cancer–related lymphoedema. British Journal of Community Nursing, 18(Suppl.), S18–S22.
STUDY PURPOSE: To assess existing research on the effectiveness of manual lymphatic drainage (MLD) as a means of preventing and/or managing lymphedema
TYPE OF STUDY: Systematic review
DATABASES USED: Google Scholar, PubMed, CINAHL
KEYWORDS: manual lymph drainage, breast cancer–related lymphoedema
INCLUSION CRITERIA: Each article had to be available in full text, published in English from 2008 to the present, regarding patients with lymphedema after breast cancer treatment. Each article needed to define lymphedema, to describe the inclusion and exclusion criteria used for patient selection, the MLD technique used, the compression strategy used, and an evaluation of severity of lymphedema.
TOTAL REFERENCES RETRIEVED: Nine references were retrieved.
EVALUATION METHOD AND COMMENTS ON LITERATURE USED: Level of evidence based on the Oxford Centre for Evidence-Based Medicine (Level 1: two systematic reviews; level 2: five randomized, controlled studies; level four: one cross-sectional descriptive study, one longitudinal observation study).
PHASE OF CARE: Multiple phases of care
Conflicting information regarding the effectiveness of MLD with variability in the application, duration, and frequency of MLD in the different studies
Authors suggested that MLD is unlikely to produce significant volume reduction when added to compression and exercise therapy. The characteristics of individual patients can affect the clinical outcomes.
Further research into the efficacy of MLD is needed.
The current standard of care for lymphedema is complete decongestive therapy, which includes MLD, compression, skin care, and exercise. Current research on individual modalities are conflicting regarding MLD. More research is needed.
Sadja, J., & Mills, P.J. (2013). Effects of yoga interventions on fatigue in cancer patients and survivors: A systematic review of randomized controlled trials. Explore, 9, 232–243.
STUDY PURPOSE: To evaluate the evidence of effects of yoga on fatigue among cancer survivors
PHASE OF CARE: Transition phase after active treatment
Eight of 10 studies only had patients with breast cancer; various stages of cancer; no standard type of yoga intervention; little consistency in measuring fatigue; high risk of selection bias in included studies. In four studies the yoga group reported significant reduction in CRF; three studies reported that there were significant reductions in participants who attended a significant number of classes; four studies reported no differences in self-reported fatigue and no association with number of classes attended.
The authors suggest that yoga may be beneficial for CRF but urge caution. Small sample sizes and lack of standardization affect ability to draw conclusions. None of the studies reported increase in fatigue, thus no evidence that yoga is detrimental. Evidence of significant reduction of fatigue with number of classes attended.
There is suggestion that yoga may be beneficial; therefore, nurses can recommend this to appropriate individuals. Adherence impacts effect; therefore, it is important that the choice of activity fit with an individual’s lifestyle. More well-conducted studies are needed.
Sadahiro, S., Suzuki, T., Tanaka, A., Okada, K., Kamata, H., Ozaki, T., & Koga, Y. (2014). Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery, 155, 493–503.
To determine comparative effectiveness of oral antibiotics and probiotics as bowel preparation in the prevention of surgical site infection (SSI)
Patients were randomized to one of three groups. The probiotic group took bifidobacteria tablets orally after each meal three times daily for seven days preoperatively, and postoperatively for 10 days. The oral antibiotic group took 0.5 g kanamycin sulfate and 0.5 g metronidazole orally three times on the day before surgery. The control group did not receive any bowel preparation beyond standard care. All patients underwent mechanical bowel prep with sodium picosulfate two days before surgery and polyethylene glycol in the morning of the day of surgery. All patients received a single preoperative 1 g dose of flomoxef IV one hour prior to incision. The same procedures for surgical site disinfection, intraperitoneal irrigation, and suture closures were done. Operative wounds were assessed daily during the hospital stay and in an outpatient clinic four weeks after surgery.
Rates of postoperative infections, including incisional infections, organ/space SSIs, and remote infections, were 24% in the probiotic group, 11.1% in the oral antibiotic group, and 25% in the control group. Group comparisons showed that the difference in infection rate was significantly lower in the oral antibiotic group than in either other group (p < .03). Incidence of incisional SSI was lower in the oral antibiotic group (p = .014). The oral antibiotic group also had a significantly lower rate of leakage (p = .004). SSI-causing pathogens were analyzed in all patients, and most of the bacteria detected were not covered by the spectrum of flomoxef. No significant differences were observed in CD toxin detection between groups.
Findings suggest that bowel preparation with oral antibiotics is helpful in preventing postoperative infections in patients with colon cancer undergoing elective colon surgery. No benefit was shown with the use of preoperative probiotics.
Findings show that rates of postoperative infections among patients undergoing surgery for colon cancer can be reduced by the addition of oral antibiotics as part of bowel preparation. Probiotic use was not effective. Nurses can advocate for consideration of use of preoperative oral antibiotics as examined in this study and advocate for further research to confirm these findings. CD risk was not shown to be different across groups in this study, but this risk remains a consideration, particularly if oral antibiotic use is prolonged.