Lievens, Y., Haustermans, K., Van den Weyngaert, D., Van den Bogaert, W., Scalliet, P., Hutsebaut, L., . . . Lambin, P. (1998). Does sucralfate reduce the acute side-effects in head and neck cancer treated with radiotherapy? A double-blind randomized trial. Radiotherapy and Oncology, 47, 149–153.
To determine the efficacy of oral sucralfate in reducing radiation (RT)-induced acute complications in the treatment of patients with head and neck cancer. This study looked at mucositis and dermatitis.
Patients were given oral sucralfate at a dose of 1 gm six times a day from the onset of RT and continued during the entire treatment.
Two sites in Belgium
The study was a randomized, placebo-controlled, double-blind trial.
Dermatitis scoring scale:
Other variables analyzed were weight, tumor site, and stage; subjective tolerance; dysphagia; nausea and vomiting; dermatitis; mucositis; total dose; and daily fractionation schedule.
Of the initial 102 patients randomized, only 83 were evaluable due to issues of patient nonadherence to the protocol. Compliance was worse in the sucralfate group. There were no differences in mean scores for dermatitis or other symptoms measured between the two study groups.
No clinical evidence indicated that sucralfate reduces acute RT-induced side effects.
Liepe, K., & Kotzerke, J. (2007). A comparative study of 188Re-HEDP, 186Re-HEDP, 153Sm-EDTMP and 89Sr in the treatment of painful skeletal metastases. Nuclear Medicine Communications, 28, 623–630.
Prospective, nonrandomized study
These treatments produced mild and reversible side effects, and it is therefore a good option. It is usually used in palliation, but due to low side effects, there is possibility that it might be considered earlier in disease process. Future research could review concomitant treatment with chemotherapy.
Lienard, A., Merckaert, I., Libert, Y., Delvaux, N., Marchal, S., Boniver, J., . . . Razavi, D. (2008). Factors that influence cancer patients’ and relatives’ anxiety following a three-person medical consultation: Impact of a communication skills training program for physicians. Psycho-Oncology, 17, 488–496.
To assess the impact of communication skills training programs on changes in patients’ and relatives’ anxiety following a three-person consultation
Prior to a three-person consultation (physician/patient/caregiver), physicians who had earlier completed a basic training program were randomly assigned to complete a consolidation workshop or to a wait-list for the workshop. To gain study data, patients and relatives completed an anxiety questionnaire and a physiologic distress questionnaire (depression and anxiety) the week before and repeated the anxiety questionnaire one week after the three-person consultation. Physicians chose patients with cancer and their accompanying relatives for an audiotaped consultation. Transcription of the consultations occurred to allow a measurement of quality of consultations. Trained psychologists assessed physician skills in assessment, information, and supportive skills according to a French national rating system used in three previous studies.
A pre/post-test design was used.
No statistically significant differences were found between patients’ and relatives’ sociodemographic characteristics and disease and over time with basic training consultation and the basic training added to the consolidation workshops. A multivariate analysis of variance assessment showed significant change between time in changes in patients’ anxiety following the three-person consultation (p = 0.027). Although anxiety decreased for both patients and relatives following the consultation, none of these changes was significant. There were no significant correlations between changes in patients’ and relatives’ anxiety and physician assessment, information, and supportive skills. In further analyses (mixed-effects modeling), physician communication skills had no influence on changes in patients and relatives following a three-person consultation. Only contextual variables (e.g., type of bad news, type of information transmitted by physicians and self-reported before the consultation) had an effect on changes in anxiety and distress.
The physician training program described did not diminish patient or relative anxiety about cancer following the consultation.
The concept of nurse/patient/caregiver conversations as part of routine nursing care seems appropriate in the U.S. healthcare system that seeks to increase primary care. Although relatives’ and patients’ needs may vary, nurses have strong assessment, information-gathering, and supportive skills to promote health and coping of patients, caregiver relatives, and families either in group formats or individual forums.
Librach, S.L., Bouvette, M., De Angelis, C., Farley, J., Oneschuk, D., Pereira, J.L., . . . Canadian Consensus Development Group for Constipation in Patients With Advanced Progressive Illness. (2010). Consensus recommendations for the management of constipation in patients with advanced, progressive illness. Journal of Pain and Symptom Management, 40, 761-773.
To identify best practices for the management of constipation in patients with advanced progressive disease.
In this consensus-based guideline, the literature was reviewed and a multidisciplinary group met to develop the consensus statement. The guideline was revised and reviewed several times prior to publication.
Databases searched were PubMed and the Cochrane Library.
Search keywords were constipation, palliative care, advanced illness, laxatives, management, guidelines, and recommendations.
Inclusion and exclusion criteria were not provided.
This information was not provided. The consensus statement included only 20 references.
The consensus statement included information on the components of patient assessment, history, rectal and abdominal examination, management, goal development, and pharmacologic and nonpharmacologic interventions, as well as a best practice summary. Nonpharmacologic recommendations included maintaining adequate fluid and fiber intake, mobility, optimizing toileting with privacy, and positioning. Pharmacologic recommendations included selection of laxatives based on patient symptoms and preferences, as well as use of methylnaltrexone with opioid-induced constipation for patients who fail to respond to optimal laxative therapy. Osmotic laxatives, polyethylene glycol (PEG), and lactulose are supported by high-level evidence. Docusates and mineral oil should not be used.
The consensus statement included a summary in outline format that reviewed the information provided in the body of the article. The summary is the most useful section of the document as the information is concise but contains adequate detail. No new information is provided. In addition, a decision tree was included that may be useful. Regular assessment is needed for the management of patients with constipation.
Liberman, B., Gianfelice, D., Inbar, Y., Beck, A., Rabin, T., Shabshin, N., . . . Catane, R. (2009). Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: A multicenter study. Annals of Surgical Oncology, 16, 140–146.
To evaluate the safety and effectiveness of magnetic resonance–guided focused ultrasound palliative treatment of bone metastases in patients with painful metastatic bone lesions for which other treatment was either not effective or not feasible
The procedure was done with patients in the magnetic resonance imaging (MRI) scanner under conscious sedation and analgesia with 5–10 mg midazolam and 2–40 mg IV morphine. The dosage was determined by the patients’ previous levels of opioid treatment. Pretreatment MRI and computed tomography (CT) scans were used to identify the treatment region. Each patient was positioned on a table over a water bath containing the ultrasound transducer so that the targeted lesions were positioned over the water bath. At the beginning of the procedure, low-power sonications were done to ensure targeting accuracy, and then treatment at therapeutic power levels was done. Proton resonance frequency shift in water temperature was used to monitor accuracy of the treatment location. At the end of the procedure, contrast-enhanced MRI was used to ensure that ablation was confined to the target tissue and that there was no significant damage to surrounding tissue. Patients had follow-up at three days, two weeks, one month, and three months after treatment. When possible, follow-up was also done at six months. The three-month visit included MR scan and CT imaging. Treatment response was categorized according to criteria of the International Bone Metastases Working Party guidelines on palliative radiotherapy endpoints (partial response was a two-point drop in visual analog scale score (VAS) with no increase in pain medication, or a drop of 25% in pain medication without increase in the pain score).
The study was a prospective, uncontrolled trial.
VAS for pain level
Thirty-six treatments were done, targeting 32 lesions. Average length of treatment was 66 minutes (range = 22–162 minutes). Average sonication energy was 1,135 joules (range = 440–1890 J). No device-related adverse events were reported. Twenty-five patients reached the three-month follow-up time point. In these evaluable patients, mean VAS score before treatment was 5.9; at three days after treatment, mean score was 3.8; and at three months, mean score was 1.8 (p < 0.003). At three months, 72% of patients had a significant reduction in pain (> 2 points), and 50% of patients had no pain. Overall, 36% had complete response and 36% had partial response as defined by the criteria used.
Findings demonstrated effective palliation of bone pain with MR-guided focused ultrasound treatment.
This procedure has promise for control of pain from bone metastases in patients who have not responded to other treatment, and, with further research, may have the potential for broader application. Further well-designed research comparing outcomes with this procedure versus that of other current approaches is warranted. Additional research to identify predictors of positive outcomes and those patients for whom this is most likely to be effective and practical according to lesion location would be useful.
Liao, S.F. (2015). Lymphedema characteristics and the efficacy of complex decongestive physiotherapy in malignant lymphedema. American Journal of Hospice and Palliative Care. Advance online publication.
To review the efficacy of complex decongestive physiotherapy (CDP) in patients with malignant lymphedema (LE) and to identify predictors for and characteristics of outcomes
Retrospective
Excess circumference decreased, and CDP efficacy as defined by the PREV was 46.6%. Pain scores improved from 4.8 to 2.8. Shoulder range of motion improved from a mean of 151.7 to 159.7.
The authors demonstrated that intensive CDP improved lymphedema volume, pain, heaviness, tension, and range of motion in a small study of patients with malignant LE.
Previous thoughts or teachings may have suggested that cancer could be spread by manual lymphatic drainage. This study shows the importance of early treatment in patients with malignant LE with CDP, providing improvements in limb volume and range of motion. Patient tolerance and variations in bandaging were not clearly identified in this study, and these may require modifications to the patient’s comfort level.
Liao, S.F., Li, S.H., Huang, H.Y., Chen, S.T., Kuo, S.J., Chen, D.R., & Wei, T.S. (2013). The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in breast cancer-related lymphedema (BCRL). Breast, 22, 703–706.
To estimate the efficacy of and predictive factors for response to complete decongestive physical (CDP) therapy in women with breast cancer-related lymphedema
Retrospective review of records was done to describe results of a CDP program and analyze factors that might predict outcomes and CDP response. The CDP program consisted of 10–26 sessions of manual lymph drainage, compression therapy for 23 hours per day, remedial exercise, and skin and nail care instructions.
The study was conducted at a single-site, outpatient setting in Taiwan.
Patients were undergoing mutliple treatment phases of care.
The study used a retrospective, observational design.
Findings suggest that baseline lymphedema and age are significantly related to longer-term response to CDP for lymphedema management.
This study provides little new information regarding efficacy of CDP in management of lymphedema in women with breast cancer. Findings show that initial severity of lymphedema may predict response to CDP, which suggests that early intervention for lymphedema can be important.
Liao, S.F., Li, S.H., & Huang, H.Y. (2012). The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of response to CDP in lower limb lymphedema (LLL) after pelvic cancer treatment. Gynecologic Oncology, 125(3), 712–715.
To evaluate the efficacy of an intensive complete decongestive physical (CDP) therapy program and identify predictive factors of response in lower-limb lymphedema
Women with unilateral LLL underwent a CDP program of 10–24 sessions that included 45 minutes of manual lymph drainage, compression therapy for 23 hours a day, and remedial exercise and instructions for skin and nail care.
The study was conducted at a single-site with multiple settings in Taiwan.
The study looked at mutliple phases of care.
The study used a retrospective review design.
Circumference measurements were used to calculate lymphedema volume.
Findings suggest that CDP is beneficial for management of lower-limb lymphedema. The lymphedema volume difference in the affected limb was directly correlated with response to CDP.
Findings suggest that CDP is beneficial for management of lower-limb lymphedema in patients treated for pelvic cancers. This is one of few studies for lower-limb lymphedema management. Nurses can educate and support patients in adhering to a CDP program to manage lymphedema. The authors noted that compliance with compression bandaging is a critical component of CDP, and nurses need to emphasize this with patients.
Liao, M.N., Chen, P.L., Chen, M.F., & Chen, S.C. (2010). Effect of supportive care on the anxiety of women with suspected breast cancer. Journal of Advanced Nursing, 66, 49–59.
To test the hypothesis that women with suspected breast cancer who received a supportive care intervention during the diagnostic phase of care would have lower anxiety than those having usual care
The intervention was supportive care, emotional support, and educational information provided by nurses through three individual meetings and two telephone calls.
Patients were undergoing the diagnostic phase of care.
A randomized controlled trial design was used.
State-Trait Anxiety Inventory (STAI)
Women in the intervention group had significantly lower state anxiety before biopsy and after learning the result compared to the control group (p = 0.008; p = 0.001).
Women with suspected breast cancer who received the supportive care program had lower anxiety than those receiving routine care.
Though resulting differences between groups were statistically significant, differences in scores between groups ranged from 1.14 to 2.12 on average, in a possible 80-point scale. The clinical relevance of this small difference is questionable, and the level of anxiety indicated by scores was still severe.
Liao, M.N., Chen, S.C., Lin, Y.C., Chen, M.F., Wang, C.H., & Jane, S.W. (2014). Education and psychological support meet the supportive care needs of Taiwanese women three months after surgery for newly diagnosed breast cancer: A non-randomised quasi-experimental study. International Journal of Nursing Studies, 51, 390–399.
To investigate the effects of education and psychological support on anxiety, symptom distress, social support, and unmet supportive care needs of Taiwanese women newly diagnosed with breast cancer over three months following surgery
Education and psychological support was provided in the form of three individual face-to-face sessions and two telephone follow-up sessions. A standardized educational booklet was used. Sessions were done at the first postoperative visit, the first chemotherapy session, and three months after surgery. The telephone follow-up call was made seven days before chemotherapy and two months after surgery. Study measures were obtained at baseline, one month after surgery, and three months after surgery.
Two-group, nonrandomized, quasiexperimental study
All forms were in Chinese.
The experimental group experienced lower levels of overall unmet supportive care needs and had lower levels of unmet needs in other dimensions as well. Levels of state anxiety and symptom distress also were lower in this group. Primary concerns across groups were self-care and supportive care. Anxiety declined in both groups at similar levels by the first follow-up measure. By three months after surgery, there was a greater reduction in anxiety scores in the experimental group, which were significantly lower than those of the control group (p < .001).
The educational and psychological support components of the intervention improved the unmet supportive care needs of patients newly diagnosed with breast cancer three months after surgery.