Urea-Based Topical Treatment
Urea-containing lotion and creams are emollients for topical use and have keratolytic properties. Urea hydrates and breaks down the intercellular matrix, which results in mild debridement and proportion of normal healing of surface lesions. Urea lotion and urea-based products were evaluated in patients with cancer for prevention and management of radiodermatitis and skin effects.
Urea-Based Moisturizer for Kinase Inhibitor-Induced Nail Toxicity
Urea-containing lotion and creams are emollients for topical use and have keratolytic properties. Urea hydrates as well as breaks down the intercellular matrix which results in mild debridement and proportion of normal healing of surface lesions. Urea-based moisturizer was evaluated for its effect on nail toxicities in patients receiving kinase inhibitors. As mechanisms of toxicity with various antitumor agents differ, effects may also differ accordingly.
Urea and Hyaluronic Acid - Topical
Hyaluronic acid, also known as hyaluronate, is a carbohydrate substance that is present in connective, epithelial, and nerve tissues and is a major component of the intracellular matrix. Urea-containing lotion and creams are emollients for topical use and have keratolytic properties. Urea hydrates and breaks down the intercellular matrix, which results in mild debridement and proportion of normal healing of surface lesions. The topical combination of urea and hyaluronic acid was evaluated in patients with cancer for the management of radiodermatitis.
Quetiapine
Quietiapine is an antipsychotic that has been used to treat schizophrenia and biopolar disorder. It is a dopamine, serotonin, and adrenergic antagonist and a potent antihistamine. Quietiapine was studied in patients with cancer for its effect on sleep disturbance.
Oxycodone/Naloxone
Oxycodone is an opiate analgesic. Naloxone is a competitive opioid-receptor antagonist.
Orientation and Information Provision
Orientation and information provision is the act of providing patients and others information about their disease, treatment, and services to be provided. This often includes general information about the organization, staff members with whom the patient may interact, physical structures and layout, and transportation or parking. The intervention differs from psychoeducational interventions in that it is not interactive with patients or families and does not include components such as support or counseling. Orientation and information provision may be done via print or electronic media.
Oral Palonosetron
Palonosetron is an antiemetic agent that is a type of 5HT3 receptor antagonist. This group of agents suppresses nausea and vomiting by inhibiting the binding of serotonin to 5HT3 receptors, which can be found in the chemoreceptor trigger zone in the central nervous system. An oral formulation of this medication was studied for its effectiveness in preventing chemotherapy-induced nausea and vomiting in patients with cancer.
Oral Care Protocol
An oral care protocol is a prescribed, routine care plan that clinicians use to educate and treat patients with cancer for oral care. The foundation of an oral care protocol is good oral hygiene. A protocol should include brushing the teeth with a soft toothbrush. If patients routinely floss, then flossing should be continued unless the patient has a risk of bleeding because of thrombocytopenia or other concerns. Various protocols may include different cleansing and treatment regimens.
Oral Branched-Chain Amino Acids
Branched-chain amino acids are essential amino acids in which the chemical configuration has a branched shape. Tryptophan, an amino acid precursor of serotonin, is thought to play a role in the pathogenesis of cancer anorexia. Uptake of tryptophan into the brain is regulated by a specific transport system, which is competitively shared with the other amino acids, branched-chain amino acids.
Oral Alkalization
SN-38, the active metabolite of irinotecan, has absorption characteristics of weakly basic drugs. Alkalization of the intestinal lumen may reduce reabsorption of SN-38 and its attendant side effects. This approach has been examined related to the topic of diarrhea.